Arlt, F. A.; Breuer, A.; Trampenau, E.; Boesl F.; Kirchner M.; Mertins, P.; Sánchez-Sendín, E.; Nasouti, M.; Mayrhofer, M.; Blüthner, M.; Endres, M.; Prüss, H.; Franke, C.

High serum prevalence of autoreactive IgG antibodies against peripheral nerve structures in patients with neurological post-COVID-19 vaccination syndrome

Front. Immunol. 2024, 15
> https://doi.org/10.3389/fimmu.2024.1404800

Keywords: SARS-CoV-2 vaccination, COVID-19 vaccination, post-COVID-19 vaccination syndrome (PCVS), autoantibody, peripheral nerve, neurofilament autoantibodies, DFS-70
Conclusion: Our data suggest that autoantibodies against nervous system tissue could be relevant in PCVS patients. Autoantibodies against neurofilaments and cell nuclei with so far non-established links to this …weiterlesen disease spectrum should be further elucidated to determine their biomarker potential.

Proal, A.

Pathogen Reactiviation – Dr Amy Proal discusses

ME Research UK
> https://www.meresearch.org.uk/pathogen-reactiviation-dr-amy-proal-discusses/

Bourgonje, A.R., Hörstke, N.V., Fehringer, M. et al.

Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn’s disease and chronic fatigue syndrome

Microbiome 12, 141 (2024)
> https://doi.org/10.1186/s40168-024-01858-1

Conclusion: These findings suggest that antibody binding to the N-terminal domain of stimulator and silent flagellins may impact TLR5 activation in both CD and ME/CFS patients. Blocking this interaction could …weiterlesen lead commensal bacteria to be recognized as pathogenic evaders, potentially contributing to dysregulation in both diseases. Furthermore, elevated antibody binding to the C-terminal domain of stimulator flagellins in CD may explain pathophysiological differences between the diseases. Overall, these results highlight the diagnostic potential of these antibody responses and lay a foundation for deeper mechanistic studies of flagellin/TLR5 interactions and their impact on innate/adaptive immunity balance.

Muirhead, N.L.; Vyas, J.; Ephgrave, R.; Singh, R.; Finlay, A.Y.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Impact on Quality of Life (QoL) of Persons with ME/CFS

Medicina 2024, 60, 1215
> https://doi.org/10.3390/medicina60081215

Keywords: myalgic encephalomyelitis; chronic fatigue syndrome; quality of life

Kratzer B, Gattinger P, Trapin D, et al.

Differential decline of SARS-CoV-2-specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID-19

Allergy. 2024; 00: 1-20
> https://doi.org/10.1111/all.16210

Keywords: CD19+CD27+ B memory cells, COVID-19, leukopenia, long-term effect, recent thymic emigrants, SARS-CoV-2, specific antibody decline, Th1/Th2 cytokine shift
Conclusion: CD19+CD27+ B memory cells, COVID-19, leukopenia, long-term effect, recent thymic emigrants, SARS-CoV-2, specific antibody decline, Th1/Th2 cytokine shift

Bonzano, S.; Dallorto, E.; Bovetti, S.; Studer, M.; De Marchis, S.

Mitochondrial regulation of adult hippocampal neurogenesis: Insights into neurological function and neurodevelopmental disorders

Neurobiology of Disease, 2024, Vol. 199, 106604
> https://doi.org/10.1016/j.nbd.2024.106604

Keywords: Mitochondria; Nr2f1; BBSOAS; Adult neural stem cells; Dentate gyrus

Löhn, M., Wirth, K.J.

Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone

J Transl Med 22, 630 (2024)
> https://doi.org/10.1186/s12967-024-05412-3

Keywords: TRPM3 channel; Myalgic Encephalomyelitis/Chronic fatigue syndrome; ME/CFS; Post-COVID syndrome; Long-COVID; Exercise intolerance; GABA; Small fiber neuropathy; Naltrexone
Conclusion: Investigating TRPM3 dysfunction in ME/CFS and PCS is crucial for advancing our understanding of the pathophysiology of these conditions. TRPM3 dysfunction is relevant to the pathophysiology of ME/CFS …weiterlesen at three critical levels: in NK cells, sensory nerve fibers, and the brain.This dysfunction may contribute to the immunological disturbances, skeletal muscle dysfunction, and neurological symptoms observed in ME/CFS and PCS. Thus, TRPM3 dysfunction holds significant pathophysiological potential in relation to ME/CFS. Given the existence of multiple splice variants of the TRPM3 channel, each affecting channel properties significantly, it is important to investigate whether specific splice variants contribute to TRPM3 dysfunction and constitute significant risk factors for the development of ME/CFS. Improving TRPM3 dysfunction in small nerve fibers and the brain with low-dose naltrexone (LDN) may better explain its clinical efficacy in ME/CFS than solely targeting TRPM3 function in NK cells.

Hunt, K.; Maclean, A.; Locock, L.; O’Dwyer, C.; Nettleton, S.; Ziebland, S.; Wild, C.

Young adults’ experiences of biographical retrogression whilst living with long COVID

Sociology of Health & Illness 2024, 1–21
> https://doi.org/10.1111/1467-9566.13798

Keywords: biographical disruption, biographical retrogression, experience of illness, long COVID, young people

Fineberg, H.V.; Brown, L.; Worku, T.; Goldowitz, I. (Editors)

A Long COVID Definition: A Chronic, Systemic Disease State with Profound Consequences (Consensus Study Report)

National Academies of Sciences, Engineering, and Medicine. 2024 – Washington, DC: The National Academies Press
> https://doi.org/10.17226/27768

Thoma, M.; Froehlich, L.; Hattesohl, D.B.R.; Quante, S.; Jason, L.A.; Scheibenbogen, C.

Why the Psychosomatic View on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Inconsistent with Current Evidence and Harmful to Patients

Medicina 2024, 60, 83
> https://doi.org/10.3390/medicina60010083

Keywords: myalgic encephalomyelitis; chronic fatigue syndrome; ME/CFS
Conclusion: False Psychosomatic Attributions on the Etiology of ME/CFS Hinder Adequate Patient Care. Even though, in recent years, more and more healthcare practitioners view ME/CFS correctly as a somatic …weiterlesen illness, there are still widespread views in the medical community of ME/CFS being a psychosomatic illness. These views are detrimental for affected patients as they can result in misdiagnosis and harmful therapies, such as GET, which can result in lasting worsening of symptoms. Moreover, false psychosomatic attributions lead to stigmatization. A correct biomedical understanding of ME/CFS in line with the current state of empirical evidence for treatment is, therefore, essential to providing adequate care to patients with ME/CFS.

Siehe auch Deutschen Gesellschaft für ME/CFS
> https://www.mecfs.de/publikation-zur-psychosomatischen-sicht-auf-me-cfs/