Neues aus Forschung und Versorgung

# Einträge: 36

13. September 2024

Dacosta-Aguayo, R.; Torán-Monserrat, P.; Carmona-Cervelló, M.; et al.

Multimodal neuroimaging in Long-COVID and its correlates with cognition 1.8 years after SARS-CoV-2 infection: a cross-sectional study of the Aliança ProHEpiC-19 Cognitiu

Front. Neurol., 15:1426881 (2024)
> https://doi.org/10.3389/fneur.2024.1426881

Keywords: diffusion tensor imaging, resting state, Long-COVID, cognition, multimodal neuroimaging, connectivity

7. September 2024

Camporesi, A.; Morello, R.; La Rocca, A.; et al.

Characteristics and predictors of Long Covid in children: a 3-year prospective cohort study

eClinicalMedicine, Volume 76, 102815
> https://doi.org/10.1016/j.eclinm.2024.102815

Keywords: SARS-CoV-2 infection; Children; Long covid; Post-covid condition; Risk factors; SARS-CoV-2 variants; COVID-19 vaccination

6. September 2024

McAndrew, F.; Abeysuriya, R.G.; Sacks-Davis, R.; et al.

Admission screening testing of patients and staff N95 respirators are cost-effective in reducing COVID-19 hospital-acquired infections

Journal of Hospital Infection, Volume 152, 81 – 92
> https://doi.org/10.1016/j.jhin.2024.06.015

Keywords: COVID-19; Agent-based model; Outbreak; Acute care; Hospital-acquired infections; Cost-effectiveness

6. September 2024

Haunhorst, S., Dudziak, D., Scheibenbogen, C. et al.

Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome

Infection (2024)
> https://doi.org/10.1007/s15010-024-02386-8

Keywords: Post-exertional malaise; Post COVID condition; Physical activity; SARS-CoV-2; ME/CFS
Conclusion: In this literature review we discuss evidence that several homeostatic functions and regulatory mechanisms that are involved in physiological adaption to exercise are dysfunctional in patients …weiterlesen experiencing PEM in PCC and ME/CFS. The accumulation of lactate, ROS, and the deprivation of cellular energy sources upon increased metabolic demand contributes significantly to lower exercise capacity. The complex dynamics of immunometabolic downstream effects may also lead to delayed and prolonged symptom exacerbations and dysregulated recovery. In particular, the disturbed metabolic homeostasis and consecutive ionic imbalance can lead to secondary muscle and mitochondrial damage and immune activation. Hence, exceeding their already reduced activity capacities enters affected patients into a recurrent and self-propagating loop. Considering the results of this review, it bears noting that we narratively synthesized and contextualized the results of multiple separate studies with different research focuses. There has not been a study that provided conclusive evidence for one disease etiology, which means that the described pathophysiological observations do not necessarily coexist. For that reason, future studies should look deeper into pathophysiological connections between herein highlighted systems, such as immunometabolic signatures that are associated with the development of PEM. Beyond that, activity prescriptions should take the pathophysiological mechanisms of PCC and ME/CFS into account to attenuate the risk of provoking PEM.

4. September 2024

Narasimhan, H.

Long COVID inflicts deep scars on the lungs, but targeting specific immune cells could reverse damage − new research in mice

The Conversation
> https://theconversation.com/long-covid-inflicts-deep-scars-on-the-lungs-but-targeting-specific-immune-cells-could-reverse-damage-new-research-in-mice-237925

4. September 2024

Rosa-Souza, F.J., Freire, Y.A., Galliano, L.M. et al.

Association of physical symptoms with accelerometer-measured movement behaviors and functional capacity in individuals with Long COVID

Sci Rep 14, 20652 (2024)
> https://doi.org/10.1038/s41598-024-71589-8

Keywords: Post-acute COVID-19 syndrome; Exercise; Functional status

29. August 2024

Lu, S., Peluso, M.J., Glidden, D.V. et al.

Early biological markers of post-acute sequelae of SARS-CoV-2 infection

Nat Commun 15, 7466 (2024)
> https://doi.org/10.1038/s41467-024-51893-7

Keywords: Biomarkers; Infectious diseases; Viral infection

28. August 2024

Ryu, J.K., Yan, Z., Montano, M. et al.

Fibrin drives thromboinflammation and neuropathology in COVID-19

Nature (2024)
> https://doi.org/10.1038/s41586-024-07873-4

Keywords: Biologics; Infection; Neuroimmunology

26. August 2024

Lavanya Visvabharathy, Neda Dalil, Lucia Leonor, Chengsong Zhu, Zachary S. Orban, Millenia Jimenez, Patrick H. Lim, Pablo Penaloza-MacMaster, Igor J. Koralnik

Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC

Immunohorizons (2024) 8 (8): 577–585
> https://doi.org/10.4049/immunohorizons.2400033

25. August 2024

Johnson, C.

Landmark Two-Day ME/CFS Exercise Study Pt 2: The Treatment Section

Health Rising
> https://www.healthrising.org/blog/2024/08/25/landmark-chronic-fatigue-exercise-study-treatments/

Keywords: Chia, Cryotherapy, Exercise, Homepage, Lapp, Levine, Liptan, ME/CFS, Mindfulness, Pacing, Physical Therapy, Treatment, Vagus nerve stimulation