Neues aus Forschung und Versorgung

# Einträge: 36

15. August 2024

Johnson, C.

Study Finds Fatigued ME/CFS Brains Unable to Adapt to Cognitive Stress

Health Rising
> http://healthrising.org/blog/2024/08/15/chronic-fatigue-syndrome-brain-cognitive-stressor/

Keywords: brain, cardiovascular, ion channels, neurovascular coupling
Conclusion: If the authors are correct then cognitive stress at least temporarily impairs the ability of the brain to speed resources (in the form of oxygen in the blood) to parts of the brain that need it – …weiterlesen producing fatigue. (That sounds like postexertional malaise of the brain to me.)

15. August 2024

Leon Bhowmik, Md. Kutubul Hasan, Tahmina Akter Bristy, et al.

A Comparison of COVID-19 and post-COVID-19 Syndrome Among Symptomatic and Asymptomatic Patients in Bangladesh: A Retrospective Cohort Study

Heliyon, 2024, e36202
> https://doi.org/10.1016/j.heliyon.2024.e36202.

Keywords: COVID-19, post-COVID-19, symptomatic, asymptomatic; risk factors
Conclusion: It was concluded that age, duration of illness, presence of respiratory distress, blood group, and disease severity are major risk factors for the development of post-COVID-19 syndrome.

13. August 2024

Nelson, C.

New Study Identifies Profile of Long Covid in Blood DNA

Albany Med Health System
> https://www.albanymed.org/news/study-identifies-profile-of-long-covid/

11. August 2024

Van Tin, H.; Rethi, L.; Higa, S.; Kao, Y.-H.; Chen, Y.-J.

Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-κB Signaling.

Cells 2024, 13
> https://doi.org/10.3390/cells13161331

Keywords: angiotensin-converting enzyme 2; cardiac fibroblasts; NLRP3 inflammasome; spike protein
Conclusion: S1 activates human CFs by priming NLRP3 inflammasomes through NF-κB signaling in an ACE2-dependent manner.

6. August 2024

Hammer, S., Monaca, C., Hoelz, A., Tannheimer, M., Huckels-Baumgart, S., Dornieden, K., Lüttel, D., Rall, M., & Müller, H.

“Im Endeffekt ist man auf sich allein gestellt.” Eine qualitative Analyse von Versorgungsbarrieren aus der Sicht Long COVID-Betroffener.

Zenodo 2024
> https://doi.org/10.5281/zenodo.13088064

Keywords: Long COVID, Post COVID, Qualitative Forschung, Versorgungsforschung, Patientenperspektive
Conclusion: Um Menschen mit Long COVID eine adäquate medizinische und soziale Versorgung zu gewährleisten, sind eine zügige Aus- und Weiterbildung aller beteiligten Akteure sowie die Entwicklung und der Ausbau …weiterlesen spezifischer Versorgungsangebote dringend erforderlich.

2. August 2024

Arlt, F. A.; Breuer, A.; Trampenau, E.; Boesl F.; Kirchner M.; Mertins, P.; Sánchez-Sendín, E.; Nasouti, M.; Mayrhofer, M.; Blüthner, M.; Endres, M.; Prüss, H.; Franke, C.

High serum prevalence of autoreactive IgG antibodies against peripheral nerve structures in patients with neurological post-COVID-19 vaccination syndrome

Front. Immunol. 2024, 15
> https://doi.org/10.3389/fimmu.2024.1404800

Keywords: SARS-CoV-2 vaccination, COVID-19 vaccination, post-COVID-19 vaccination syndrome (PCVS), autoantibody, peripheral nerve, neurofilament autoantibodies, DFS-70
Conclusion: Our data suggest that autoantibodies against nervous system tissue could be relevant in PCVS patients. Autoantibodies against neurofilaments and cell nuclei with so far non-established links to this …weiterlesen disease spectrum should be further elucidated to determine their biomarker potential.

31. Juli 2024

Proal, A.

Pathogen Reactiviation – Dr Amy Proal discusses

ME Research UK
> https://www.meresearch.org.uk/pathogen-reactiviation-dr-amy-proal-discusses/

29. Juli 2024

Bourgonje, A.R., Hörstke, N.V., Fehringer, M. et al.

Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn’s disease and chronic fatigue syndrome

Microbiome 12, 141 (2024)
> https://doi.org/10.1186/s40168-024-01858-1

Conclusion: These findings suggest that antibody binding to the N-terminal domain of stimulator and silent flagellins may impact TLR5 activation in both CD and ME/CFS patients. Blocking this interaction could …weiterlesen lead commensal bacteria to be recognized as pathogenic evaders, potentially contributing to dysregulation in both diseases. Furthermore, elevated antibody binding to the C-terminal domain of stimulator flagellins in CD may explain pathophysiological differences between the diseases. Overall, these results highlight the diagnostic potential of these antibody responses and lay a foundation for deeper mechanistic studies of flagellin/TLR5 interactions and their impact on innate/adaptive immunity balance.

16. Juli 2024

Muirhead, N.L.; Vyas, J.; Ephgrave, R.; Singh, R.; Finlay, A.Y.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Impact on Quality of Life (QoL) of Persons with ME/CFS

Medicina 2024, 60, 1215
> https://doi.org/10.3390/medicina60081215

Keywords: myalgic encephalomyelitis; chronic fatigue syndrome; quality of life

14. Juli 2024

Kratzer B, Gattinger P, Trapin D, et al.

Differential decline of SARS-CoV-2-specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID-19

Allergy. 2024; 00: 1-20
> https://doi.org/10.1111/all.16210

Keywords: CD19+CD27+ B memory cells, COVID-19, leukopenia, long-term effect, recent thymic emigrants, SARS-CoV-2, specific antibody decline, Th1/Th2 cytokine shift
Conclusion: CD19+CD27+ B memory cells, COVID-19, leukopenia, long-term effect, recent thymic emigrants, SARS-CoV-2, specific antibody decline, Th1/Th2 cytokine shift