Neues aus Forschung und Versorgung

Class, J., Simons, L.M., Lorenzo-Redondo, R. et al.

Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification

Nat Microbiol (2024)
> https://doi.org/10.1038/s41564-024-01786-8

Keywords: SARS-CoV-2, Viral evolution, Virus–host interactions

Darbyshire, J; Greenhalgh, T; Bakerly, N D; et al.

Improving Quality in Adult Long Covid Services: Findings from the LOCOMOTION Quality Improvement Collaborative

Clinical Medicine, 2024
> https://doi.org/10.1016/j.clinme.2024.100237

Keywords: covid-19; long covid; post covid-19 syndrome; post covid-19 condition; quality improvement collaborative; postural orthostatic tachycardia syndrome; breathing pattern disorder; post-exertional malaise; post-exertional symptom exacerbation

Becker, R.C., Tantry, U.S., Khan, M. et al.

The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management

J Thromb Thrombolysis (2024)
> https://doi.org/10.1007/s11239-024-03028-4

Keywords: COVID-19-associated thrombosis; Microvascular thrombosis; Macrovascular thrombosis

Gross, R. S.; Thaweethai T.; Kleinman L. C.; et al.

Characterizing Long COVID in Children and Adolescents

JAMA. Published online 2024
> https://doi.org/10.1001/jama.2024.12747

Conclusion: This study developed research indices for characterizing PASC in children and adolescents. Symptom patterns were similar but distinguishable between the 2 groups, highlighting the importance of …weiterlesen characterizing PASC separately for these age ranges.

Ewing, A.; Joffe, D.; Blitshteyn, S.; et al.

Long COVID Clinical Evaluation, Research and Impact on Society: A Global Expert Consensus

SSRN – preprints with THE LANCET
> https://ssrn.com/abstract=4931063

Keywords: Long COVID, Definition, Diagnosis, Treatment, Research, Societies
Conclusion: This modified Delphi study is the first to provide international consensus regarding the clinical evaluation and medical investigation of Long COVID with expert consensus recommendations to …weiterlesen physicians. Gaining consensus agreement from 179 experts around the globe we establish conditions for diagnosis of different subgroups within the Long COVID umbrella. Strong consensus was gained for assessment and treatment of Long COVID-associated conditions, including POTS, MCAS, insomnia, new onset dyslipidaemia, diabetes, and hypertension. Consensus was also achieved that cardio-metabolic disturbance should be ruled out before prescribing graded exercise therapy as treatment. Biomarkers, where available, may be useful when monitoring treatment response to Long COVID. Our expert panel agreed that further research was urgently needed for Long COVID. It was recommended that an international task force should be developed to oversee research priorities and facilitate/encourage global collaborative efforts and data sharing. Clear consensus was reached that the impacts of COVID-19 infection on children should be a research priority (e.g. prevention of transmission in schools, long-term impacts of infections, impacts on learning/development, etc). Consensus was also reached on the need to determine the effects of Long COVID on societies and economies, and that governments need to prioritise investment in public health protections to prevent reinfections.

University of Colorado at Boulder

The Invisible Damage: How COVID Rewires Our Brains

SciTechDaily – Health
> https://scitechdaily.com/the-invisible-damage-how-covid-rewires-our-brains/

Keywords: Cortisol, COVID-19, Infectious Diseases, Long COVID, Neuroscience, University of Colorado at Boulder

siehe auch
> https://doi.org/10.1016/j.bbi.2024.07.034

Palmer, C.S., Perdios, C., Abdel-Mohsen, M. et al.

Non-human primate model of long-COVID identifies immune associates of hyperglycemia

Nat Commun 15, 6664 (2024)
> https://doi.org/10.1038/s41467-024-50339-4

Keywords: Experimental models of disease, Metabolic disorders, SARS-CoV-2, Viral infection

Marciulynaite, J.; Sileikiene, R.; Snipaitiene, A.

Severe Post-Viral Polymyositis after COVID-19 in Childhood: A Case Report and Literature Review.

Children 2024, 11, 1011
> https://doi.org/10.3390/children11081011

Keywords: myositis; polymyositis; post-viral; post-COVID; SARS-CoV-2; children; pediatric
Conclusion: In conclusion, this clinical case reveals a relatively new and poorly studied post-infectious variant of severe polymyositis in a child with previous COVID-19 infection. This is an example of …weiterlesen successful immunosuppressive therapy, which led to a great improvement in the patient’s clinical condition and laboratory markers. As the data about this condition in children are lacking, more clinical experience and further studies are necessary to explain the mechanisms of post-COVID-induced autoimmune pathologies and find the most appropriate management solution.

Mandhane P. J.

Notice of Retraction: Hahn LM, et al. Post–COVID-19 Condition in Children. JAMA Pediatrics. 2023;177(11):1226-1228.

JAMA Pediatr. 2024
> https://doi.org/10.1001/jamapediatrics.2024.2996

Costantino, V., Grafton, Q., Kompas, T., Chu, L., Honeyman, D., Notaras, A. and MacIntyre, C.R.

The public health and economic burden of long COVID in Australia, 2022–24: a modelling study

Med J Aust, (2024) 221: 217-223
> https://doi.org/10.5694/mja2.52400

Conclusion: Widespread SARS-CoV-2 infections in Australia mean that even a small proportion of infected people developing long COVID-related illness and disability could have important population health and …weiterlesen economic effects. A paradigm shift is needed, from a sole focus on the immediate effects of coronavirus disease 2019 (COVID-19) to preventing and treating COVID-19 and treating long COVID, with implications for vaccine and antiviral policy and other mitigation of COVID-19.